| Alec Baldwin | Dr. Kennebrew Beauregard | |
| Isiah Whitlock Jr. | Mr. Turrentine | |
| Brian Tarantina | Officer Clay Mulaney | |
| Ken Garito | Sergeant Trapp | |
| Adam Driver | Flip Zimmerman | |
| Laura Harrier | Patrice Dumas |
| John David Washington | Ron Stallworth | |
| Robert John Burke | Chief Bridges | |
| Arthur J. Nascarella | Officer Wheaton | |
| Frederick Weller | Master Patrolman Andy Landers | |
| Michael Buscemi | Jimmy Creek | |
| Damaris Lewis | Odetta |