| Robin Williams | Patch Adams | |
| Monica Potter | Carin | |
| Bob Gunton | Dean Walcott | |
| Irma P. Hall | Joletta | |
| Harve Presnell | Dean Anderson | |
| Peter Coyote | Bill Davis |
| Daniel London | Truman | |
| Philip Seymour Hoffman | Mitch | |
| Josef Sommer | Dr. Eaton | |
| Frances Lee McCain | Judy | |
| Daniella Kuhn | Adelane | |
| James Greene | Bile |