| Paul Mescal | Lucius | |
| Pedro Pascal | General Acacius | |
| Joseph Quinn | Emperor Geta | |
| Lior Raz | Viggo | |
| Peter Mensah | Jugurtha | |
| Alexander Karim | Ravi |
| Denzel Washington | Macrinus | |
| Connie Nielsen | Lucilla | |
| Fred Hechinger | Emperor Caracalla | |
| Derek Jacobi | Gracchus | |
| Matt Lucas | Master of Ceremonies | |
| Yuval Gonen | Arishat |