| Tommy Lee Jones | Kevin Brown/Agent K | |
| Linda Fiorentino | Dr. Laurel Weaver | |
| Rip Torn | Chief Agent Zed | |
| Siobhan Fallon | Beatrice | |
| Jon Gries | Nick the Van Driver | |
| Carel Struycken | Arquillian |
| Will Smith | James Darrel Edwards III/Agent J | |
| Vincent D'Onofrio | Edgar | |
| Tony Shalhoub | Jack Jeebs | |
| Mike Nussbaum | Gentle Rosenburg the Arquillian Jeweler | |
| Sergio Calderón | Jose | |
| Fredric Lehne | INS Agent Janus |