| Johnny Depp | Rango/Lars (hlas) | |
| Abigail Breslin | Priscilla (hlas) | |
| Alfred Molina | Roadkill (hlas) | |
| Stephen Root | Doc/Merrimack/Mr. Snuggles (hlas) | |
| Timothy Olyphant | Spirit of the West (hlas) | |
| Ian Abercrombie | Ambrose (hlas) |
| Isla Fisher | Beans (hlas) | |
| Ned Beatty | Mayor (hlas) | |
| Bill Nighy | Rattlesnake Jake (hlas) | |
| Harry Dean Stanton | Balthazar (hlas) | |
| Ray Winstone | Bad Bill (hlas) | |
| Gil Birmingham | Wounded Bird (hlas) |