Tobey Maguire | Spider-Man / Peter Parker | |
James Franco | Harry Osborn | |
J.K. Simmons | J. Jonah Jameson | |
Willem Dafoe | Green Goblin / Norman Osborn | |
Bruce Campbell | Snooty Usher | |
Sam Raimi | student (neoficiálně) |
Kirsten Dunst | Mary Jane Watson | |
Alfred Molina | Doc Ock / Dr. Otto Octavius | |
Dylan Baker | Dr. Curt Connors | |
Elizabeth Banks | slečna Brantová | |
John Landis | doktor | |
Ted Raimi | Hoffman |