| John Travolta | James Ubriacco | |
| Olympia Dukakis | Rosie | |
| Abe Vigoda | Grandpa | |
| Twink Caplan | Rona | |
| Jaryd Waterhouse | Mikey | |
| Christopher Aydon | Mikey |
| Kirstie Alley | Mollie Ubriacco | |
| George Segal | Albert | |
| Bruce Willis | Mikey (hlas) | |
| Jason Schaller | Mikey | |
| Jacob Haines | Mikey | |
| Joy Boushel | Melissa |