| Denzel Washington | Eli | |
| Mila Kunis | Solara | |
| Jennifer Beals | Claudia | |
| Joe Pingue | Hoyt | |
| Michael Gambon | George | |
| Chris Browning | Hijack Leader |
| Gary Oldman | Carnegie | |
| Ray Stevenson | Redridge | |
| Evan Jones | Martz | |
| Frances de la Tour | Martha | |
| Tom Waits | Engineer | |
| Richard Cetrone | Hijacker |